产品货号：
Z25438
中文名称：
RMI2抗体
英文名称：
Anti-RMI2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RMI2 Antibody |
| 指标别名 | RecQ mediated genome instability 2;BLAP18;C16orf75;RMI2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC,FCM |
| 基因名称 | RMI2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence of human RMI2(KMTDLSDNPIHESMWELEVEDLHRNIP). |
| 实际分子量 | 17KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | RMI2 is a component of the BLM (RECQL3) complex,which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability.This gene is mapped to 16p13.13.RMI1 and RMI2 were present in approximately stoichiometric amounts with other BLM complex components,including topoisomerase-3-alpha (TOP3A),RPA (see RPA1),and BLAP250.RMI2 also associated with RMI1 and TOP3A in a second complex.RMI1 and RMI2 interacted directly,and both were essential for stability of the BLM complex.Depletion of either RMI1 or RMI2 depleted the other protein by 80 to 90%.Chicken DT40 cells depleted of Rmi2 displayed elevated sister chromatid exchange,but other functions of the BLM complex appeared intact.Mutation analysis revealed that interaction between human RMI2 and BLM was essential for suppression of sister chromatid exchange. |
| Uniprot ID | Q96E14 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section 1:50～400 Immunocytochemistry in fixed cells 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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